Thyrox Tablet 25 mcg - Click Pharma

Thyrox Tablet 25 mcg 30 Pcs

33.3 ৳
Generic Name:

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Thyrox Tablet 25 mcg

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Levothyroxine Sodium


  • As replacement therapy in hypothyroidism of any aetiology. Replacement therapy should not be instituted in transient hypothyroidism during the recovery phase of subacute Thyroiditis.
  • For the suppression of Thyroid Stimulating Hormone (TSH) levels in the presence of goitres, nodules and after radiological and/or surgical treatment of Thyroid cancer.
  • For the suppression of the goitrogenic effects of other drugs such as Lithium.
  • As a diagnostic aid in suppression tests.


This tablet contains synthetic Levothyroxine (also called Thyroxine or T4) which is identical to the natural hormone T4, produced in the Thyroid gland. About 30% of T4 is converted to the much more active Triiodothyronine (T3) in peripheral tissues. TBG (Thyroxine Binding Globulin) is the major carrier of T4. This binding protects T4 from metabolism and excretion resulting in its long half-life in the circulation. Only about 0.03% of total T4 in plasma is unbound. The half-life of elimination of T4 is 6 to 7 days. In hyperthyroidism, the half-life is shortened to 3 or 4 days, whereas in hypothyroidism it may be 9 to 10 days. In conditions associated with reduced protein in plasma as in nephrosis or hepatic cirrhosis or when binding to protein is inhibited by certain drugs the half-life of T4 may be shortened. The liver is the major site of degradation of Thyroid hormones. T4 is conjugated with Glucuronic and Sulphate conjugates through the Phenolic hydroxyl group and excreted in the urine.There is an enterohepatic circulation of the Thyroid hormones, since they are liberated by hydrolysis in the intestine and reabsorbed. Because of the long half-life of T4, a steady blood level of the biologically more active T3 can be obtained from one single daily dose of Levothyroxine. Therefore, variations in the therapeutic effect are unlikely once the correct dosage has been established.


Dosage & Administration

Adult dose:

  • Initial starting dose: 25-50 meg/day, with gradual increments in dose at 6-8 week intervals, as needed. The Levothyroxine Sodium dose is generally adjusted in 12.5-25 meg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized.
  • In patients with severe hypothyroidism: Initial dose is 12.5-25 meg/day with increases of 25 meg/day every 2-4 weeks, accompanied by clinical and laboratory assessment,until the TSH level is normalized.
  • In patients with secondary (pituitary) or tertiary (hypothalamic)
  • hypothyroidism: Levothyroxine Sodium dose should be titrated until the patient is clinically euthyroid and the serum free - T4 level is restored to the upper half of the normal range.
  • For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 meg/kg/day.

Pediatric Dosage Newborns: The recommended starting dose is 10-15 meg/kg/day. A lower starting dose should be considered in infants at risk for cardiac failure and the dose should be increased in 4-6 weeks as needed based on clinical and laboratory response to treatment. In infants with very low (<5 mcg/dL) or undetectable serum T4 concentrations, the recommended initial starting dose is 50 meg/day of Levothyroxine Sodium.

Infants and Children: In children with chronic or severe hypothyroidism, initial dose of 25 meg/day with increments of 25 meg every 2-4 weeks until the desired effect is achieved. Hyperactivity in an older child can be minimized if the starting dose is one-fourth of the recommended full replacement dose and the dose is then increased on a weekly basis by an amount equal to one-fourth the full recommended replacement dose until the full recommended replacement dose is reached.

  • 0-3 months: 10-15 meg/kg/day
  • 3-6 months: 8-10 meg/kg/day
  • 6-12 months: 6-8 meg/kg/day
  • 1-5 years: 5-6 meg/kg/day
  • 6-12 years: 4-5 meg/kg/day
  • >12 years but growth and puberty incomplete: 2-3 meg/kg/day
  • Growth and puberty complete: 1.7 meg/kg/day.

The dose should be adjusted based on clinical response and laboratory parameters. In the treatment of goitres, nodules and Thyroid cancer, the objective is to ensure a constant and sufficient suppression of TSH. For suppression of TSH levels, a gradual increase in dosing is usually not necessary. For adults, the usual suppressive dosage of T4 is 2.6 meg/kg of body weight daily. When Levothyroxine Sodium is used as a diagnostic aid, the dosage depends on the type of investigation.

* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'


Concomitant use of Thyroid hormones with any of the following drugs or substances may lead to the occurrence of clinically relevant interactions:

  • Oral anticoagulants: Thyroid hormones may enhance the activity of oral anticoagulants.
  • Antidiabetic drugs: Thyroid hormones may cause increases in insulin or oral hypoglycaemic drug requirements.
  • Digitalis preparations: Thyroid hormones may alter the requirement for Digitalis preparations.
  • Cholestyramine: The absorption of Thyroid hormones may be decreased by Cholestyramine; therefore, there should be an interval of at least 4 hours between administration.
  • Phenytoin: Phenytoin appears to enhance the metabolism of Thyroid hormones and may also displace T4 from TBG.
  • Foods: In order to avoid irregular absorption Levothyroxine tablets should be taken preferably at a fixed time on an empty stomach with some fuilds. Simultaneous intake of food may decrease the absorption of T4.


Untreated subclinical or overt Thyrotoxicosis of any etiology, Acute Myocardial Infarction, Uncorrected Adrenal failure.


Side Effects

Too high a dosage may lead to symptoms of hyperthyroidism such as tachycardia, nervousness, tremor, headache, flushing, perspiration and loss of weight. If necessary, treatment can be interrupted for a few days and then be resumed at a lower dosage.

Pregnancy & Lactation

Pregnancy Category A. Pregnancy may increase Levothyroxine requirements. Although Thyroid hormones are excreted only minimally in human milk,caution should be exercised when it is administered to a nursing woman.However, adequate replacement doses of Levothyroxine are generally needed to maintain normal lactation.

Precautions & Warnings

  • In patients whose hypothyroidism is due to a decrease in pituitary gland function, there may also be adrenocortical insufficiency;before starting Levothyroxine therapy, this should be treated by adequate replacement with Corticosteroids to prevent acute adrenal insufficiency.
  • The choice of the starting dose and of any increases in dosing should be made with great care in patients with cardiovascular disease and/or severe and long-existing hypothyroidism.Too high an initial dose or too rapid an increase in dosing may lead to development or worsening of angina complaints, arrhythmias, myocardial infarction, cardiac failure or to sudden increase in blood pressure, especially in older patients.
  • Any marked change of body weight during treatment with T4 requires adjustment of the dosage.
  • When monitoring blood levels of T3 and T4, it should be borne in mind that a "high" normal to slightly increased T4 level will be necessary in order to obtain a normal level of T3.The correct dosage of Levothyroxine in primary hypothyroidism should generally be established by monitoring the serum level of TSH to see whether it has normalized.
  • Because intoxication with Thyroid preparations may have serious consequences.

Overdose Effects

Acute overdosage with Thyroid preparations may lead to a Thyrotoxic crisis. In case of an acute overdose gastrointestinal absorption should be minimized. Hospitalization for observation and possible treatment is advised.

Therapeutic Class

Thyroid drugs & hormone

Storage Conditions

Store in a cool and dry place, protect from light. Keep out of the reach of children.

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