Docusate Sodium oral preparations are indicated to prevent and treat chronic constipation, as follows:
- soften hard, dry stools in order to ease defecation and reduce straining at stool;
- in the presence of hemorrhoids and anal fissure, prevent hard, dry stools and reduce straining.
Docusate Sodium oral preparations are also used as an adjunct in abdominal radiological procedures.
Docusate sodium works by allowing more water to be absorbed by the stool. Docusate does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism. The effect of docusate may not necessarily be all due to its surfactant properties. Perfusion studies suggest that docusate inhibits fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.
Dosage & Administration
Route of administration: Oral.
- Adults and elderly: One to five Docusate Sodium oral preparations should be taken daily in divided doses. Treatment should be commenced with large doses, which should be decreased as the condition of the patient improves.
- For use with barium meals: Four Docusate Sodium oral preparations to be taken with the meal.
- Children under 12 years: Not recommended.
Docusate Sodium softgel capsules should not be taken concurrently with mineral oil.
Docusate Sodium softgel capsule is contra-indicated in patients with hypersensitivity to Docusate Sodium.
Rarely, Docusate Sodium softgel capsules can cause diarrhea, nausea, abdominal cramps or skin rash.
Pregnancy & Lactation
There are no adequate data from the use of the drug in pregnant women. Animal studies are insufficient with respect to effects on pregnancy and embryonic foetal development. The potential risk for humans is unknown. During wide use, no adverse consequences have been reported. Use in pregnancy only if the benefits outweigh the risks. Docusate sodium is excreted in breast milk and should therefore, be used with caution in lactating mothers.
Precautions & Warnings
Docusate Sodium capsule should not be administered when abdominal pain, nausea, vomiting or intestinal obstruction is present. Patients with rare hereditary problems of fructose intolerance should not take this medicine. Organic disorders should be excluded prior to the administration of any laxative. The treatment of constipation with any medicinal product is only adjuvant to a healthy lifestyle and diet, for example, increased intake of fluids and dietary fiber and advice on appropriate physical activity. If laxatives are needed every day, or if there is persistent abdominal pain, patients need to consult with physicians. Do not use this medicine if patients are intolerant to small quantities of sugar (sorbitol, fructose).
In rare cases of overdose, excessive loss of water and electrolytes should be treated by encouraging the patient to drink plenty of fluid. Electrolyte loss should be replenished where appropriate.
Store in a cool and dry place, protected from light
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