Feripon 1 Pcs

Deferiprone

Indications

Iron overload in patients with thalassaemia.

Pharmacology

Deferiprone is a chelating agent with an affinity for ferric ion (iron III). Deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. Deferiprone has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron.

Dosage & Administration

Adult: 25 mg/kg tid. Doses >100 mg/kg daily are not recommended.
Child: >6 yr: 25 mg/kg tid.

May be taken with or without food.

* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Interaction

Avoid using deferiprone with aluminium-containing antacids as it can chelates trivalent metal ions.

Contraindications

Agranulocytosis, pregnancy and lactation.

Side Effects

Musculoskeletal and joint pain; GI disturbances; red-brown discoloration of urine; transient liver enzyme abnormalities; zinc deficiency; neutropenia and agranulocytosis.

Pregnancy & Lactation

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Precautions & Warnings

Hepatic and renal impairment. Neutropenia, monitor neutrophil count wkly and discontinue treatment if neutropenia develops. Limited experience in children 6-10 yr.

Therapeutic Class

Antidote preparations

Storage Conditions

Store below 30° C.